1 publication

1 publication

An Artificial Ruthenium-Containing β-Barrel Protein for Alkene–Alkyne Coupling Reaction

Okuda, J.

Org. Biomol. Chem. 2021, 19, 2912-2916, 10.1039/d1ob00279a

A modified Cp*Ru complex, equipped with a maleimide group, was covalently attached to a cysteine of an engineered variant of Ferric hydroxamate uptake protein component: A (FhuA). This synthetic metalloprotein catalyzed the intermolecular alkene–alkyne coupling of 3-butenol with 5-hexynenitrile. When compared with the protein-free Cp*Ru catalyst, the biohybrid catalyst produced the linear product with higher regioselectivity.

Metal: Ru
Ligand type: Cp*
Anchoring strategy: ---
Optimization: ---
Max TON: 170
ee: ---
PDB: ---
Notes: ---