An Artificial Ruthenium-Containing β-Barrel Protein for Alkene–Alkyne Coupling Reaction
A modified Cp*Ru complex, equipped with a maleimide group, was covalently attached to a cysteine of an engineered variant of Ferric hydroxamate uptake protein component: A (FhuA). This synthetic metalloprotein catalyzed the intermolecular alkene–alkyne coupling of 3-butenol with 5-hexynenitrile. When compared with the protein-free Cp*Ru catalyst, the biohybrid catalyst produced the linear product with higher regioselectivity.
Metal: RuLigand type: Cp*Anchoring strategy: ---Optimization: ---Reaction: Alkene–alkyne couplingMax TON: 170ee: ---PDB: ---Notes: ---