2 publications
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Construction of Robust Bio-Nanotubes using the Controlled Self-Assembly of Component Proteins of Bacteriophage T4
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Small 2010, 6, 1873-1879, 10.1002/smll.201000772
The synthesis of a robust bio‐nanotube consisting of the β‐helical tubular component proteins of bacteriophage T4 is described. The crystal structure indicates that it has a well‐defined nanoscale length of 10 nm as a result of the head‐to‐head dimerization of β‐helices. Surprisingly, the tube assembly has high thermal stability, high tolerance to organic solvents, and a wide pH‐stability range.
Metal: CuLigand type: FlavinHost protein: [(gp5βf)3]2Anchoring strategy: Lysine-succinimideOptimization: ---Notes: ---
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Molecular Design of Heteroprotein Assemblies Providing a Bionanocup as a Chemical Reactor
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Small 2008, 4, 50-54, 10.1002/smll.200700855
A bionanocup chemical reactor is constructed from a heteroprotein assembly from bacteriophage T4. The preparation of a stable iron(III) porphyrin–bionanocup composite is described. The hydrophobic cup provides a space suitable for the fixation of low‐water‐solubility iron(III) porphyrins. The application of the iron(III) porphyrin–bionanocup composites for the catalysis of sulfoxidation of thioanisoles is demonstrated (see figure).
Metal: FeLigand type: Maleimide-protoporphyrin IXHost protein: (gp27-gp5)3Anchoring strategy: Cystein-maleimideOptimization: ---Notes: ---