An Artificial Metalloenzyme for Olefin Metathesis
A Grubbs–Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.
A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold
Capture and Characterization of a Reactive Haem– Carbenoid Complex in an Artificial Metalloenzyme
Structure of the Mb*(NMH) haem-iron complex