1 publication

1 publication

Structural Basis for Enantioselectivity in the Transfer Hydrogenation of a Ketone Catalyzed by an Artificial Metalloenzyme

Fontecilla-Camps, J.C.

Eur. J. Inorg. Chem. 2013, 2013, 3596-3600, 10.1002/ejic.201300592

The crystal structure of bovine β‐lactoglobulin bound to a complex consisting of a (η5‐Cp*)Rh(2,2′‐dipyridylamine) head and a lauric acid derived hydrophobic tail has been solved at 1.85 Å resolution. Previous work has shown that this hybrid catalyzes the transfer hydrogenation of an aryl ketone in neat water with formate as hydrogen donor with enantiomeric excess (ee) of about 26 %. Calculations using the X‐ray model indicate that the complex head can adopt discrete conformations, which may explain the ee observed.

Metal: Rh
Ligand type: 2,2'-Dipyridylamine; Cp*
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: 26
Notes: ---