Studies on the Oxidase Activity of Copper (II) Carboxypeptidase A
J. Chem. Soc., Chem. Commun. 1976, 830, 10.1039/C39760000830
Copper(II) carboxypeptidase A catalyses the oxidation of ascorbic acid and this reaction is inhibited by α-benzylsuccinate, a known inhibitor of the thiolesterase action of the copper enzyme; the pH dependencies of kcat and kcat/Km are similar near pH 7 to those seen for the peptidase and esterase activities of native carboxypeptidase A.
Metal: CuLigand type: Amino acidHost protein: Carboxypeptidase AAnchoring strategy: Metal substitutionOptimization: ---Reaction: OxidationMax TON: ---ee: ---PDB: ---Notes: Oxidation of vitamin C