2 publications

2 publications

A Palladium-Catalyst Stabilized in the Chiral Environment of a Monoclonal Antibody in Water

Arada, H.; Yamaguchi, H.

Chem. Commun. 2020, 56, 1605-1607, 10.1039/c9cc08756g

We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst of the Pd-complex with mAb selectively gives the (R)-enantiomer product.

Metal: Pd
Ligand type: Allyl; Phosphine
Host protein: Antibody
Anchoring strategy: Supramolecular
Optimization: ---
Reaction: Allylic amination
Max TON: 600
ee: 98
PDB: ---
Notes: Recalculated TON

Artificial Metalloenzymes Through Cysteine-Selective Conjugation of Phosphines to Photoactive Yellow Protein

Kamer, P.C.J.

ChemBioChem 2010, 11, 1236-1239, 10.1002/cbic.201000159

Pinning phosphines on proteins: A method for the cysteine‐selective bioconjugation of phosphines has been developed. The photoactive yellow protein has been site‐selectively functionalized with phosphine ligands and phosphine transition metal complexes to afford artificial metalloenzymes that are active in palladium‐catalysed allylic nucleophilic substitution reactions.

Metal: Pd
Ligand type: Allyl; Phosphine
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Reaction: Allylic amination
Max TON: 45
ee: ---
Notes: ---