12 publications

12 publications

Artificial Peroxidase-Like Hemoproteins Based on Antibodies Constructed from a Specifically Designed Ortho-Carboxy Substituted Tetraarylporphyrin Hapten and Exhibiting a High Affinity for Iron-Porphyrins

Mahy, J.-P.

FEBS Lett., 1996, 10.1016/0014-5793(96)01006-X


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody 13G10
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: kcat/KM = 105 M-1 * s-1

Coordination Chemistry of Iron(III)-Porphyrin-Antibody Complexes Influence on the Peroxidase Activity of the Axial Coordination of an Imidazole on the Iron Atom

Mahy, J.-P.

Eur. J. Biochem., 2002, 10.1046/j.0014-2956.2001.02670.x


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody 13G10
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: kcat/KM = 15200 M-1 * s-1

Coordination Chemistry Studies and Peroxidase Activity of a New Artificial Metalloenzyme Built by the “Trojan Horse” Strategy

Mahy, J.-P.

J. Mol. Catal. A: Chem., 2010, 10.1016/j.molcata.2009.10.016


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody 7A3
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: k1 = 574 M-1 * min-1

Enzyme Repurposing of a Hydrolase as an Emergent Peroxidase Upon Metal Binding

Fujieda, N.; Ward, T. R.

Chem. Sci., 2015, 10.1039/c5sc01065a


Metal: Cu
Ligand type: Amino acid
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: 35
ee: ---
PDB: ---
Notes: ---

Flavohemoglobin: A Semisynthetic Hydroxylase Acting in the Absence of Reductase

Kaiser, E. T.

J. Am. Chem. Soc., 1987, 10.1021/ja00236a062


Metal: Fe
Ligand type: Porphyrin
Host protein: Hemoglobin
Anchoring strategy: ---
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: ---

Helichrome: Synthesis and Enzymatic Activity of a Designed Hemeprotein

Kaiser, E. T.; Sasaki, T.

J. Am. Chem. Soc., 1989, 10.1021/ja00183a065


Metal: Fe
Ligand type: Porphyrin
Host protein: Artificial construct
Anchoring strategy: Covalent
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: Only 60 amino acids

Hemoabzymes: Towards New Biocatalysts for Selective Oxidations

Mahy, J.-P.

J. Immunol. Methods, 2002, 10.1016/S0022-1759(02)00223-5


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody 3A3
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: kcat/KM = 33000 M-1 * s-1

Hemozymes Peroxidase Activity Of Artificial Hemoproteins Constructed From the Streptomyces Lividans Xylanase A and Iron(III)-Carboxy-Substituted Porphyrins

Mahy, J.-P.

Bioconjug. Chem., 2008, 10.1021/bc700435a


Metal: Fe
Ligand type: Porphyrin
Host protein: Xylanase A (XynA)
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: kcat/KM = 1083 M-1 * s-1

Manganese Terpyridine Artificial Metalloenzymes for Benzylic Oxygenation and Olefin Epoxidation

Lewis, J. C.

Tetrahedron, 2014, 10.1016/j.tet.2014.03.008


Metal: Mn
Ligand type: Poly-pyridine
Host protein: Nitrobindin (Nb)
Anchoring strategy: Covalent
Optimization: Chemical
Max TON: 19.2
ee: ---
PDB: 3EMM
Notes: ---

Metal: Mn
Ligand type: Poly-pyridine
Host protein: Nitrobindin (Nb)
Anchoring strategy: Covalent
Optimization: Chemical
Reaction: Epoxidation
Max TON: 19.8
ee: ---
PDB: 3EMM
Notes: ---

Peroxidase Activity of an Antibody-Heme Complex

Schultz, P. G.

J. Am. Chem. Soc., 1990, 10.1021/ja00181a065


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody7G12-A10-G1-A12
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: 200-500
ee: ---
PDB: ---
Notes: ---

Studies of the Reactivity of Artificial Peroxidase-Like Hemoproteins Based on Antibodies Elicited Against a Specifically Designed ortho-Carboxy Substituted Tetraarylporphyrin

Mahy, J.-P.

FEBS Lett., 1999, 10.1016/S0014-5793(98)01703-7


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody 13G10
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: TOF = 4.7 min-1

Towards Antibody-Mediated Metallo-Porphyrin Chemistry

Keinan, E.

Pure Appl. Chem., 1990, 10.1351/pac199062102013


Metal: Mn
Ligand type: Porphyrin
Host protein: Antibody
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: 549
ee: ---
PDB: ---
Notes: ---