1 publication

1 publication

Studies on the Oxidase Activity of Copper (II) Carboxypeptidase A

Kaiser, E.T.

J. Chem. Soc., Chem. Commun. 1976, 830, 10.1039/C39760000830

Copper(II) carboxypeptidase A catalyses the oxidation of ascorbic acid and this reaction is inhibited by α-benzylsuccinate, a known inhibitor of the thiolesterase action of the copper enzyme; the pH dependencies of kcat and kcat/Km are similar near pH 7 to those seen for the peptidase and esterase activities of native carboxypeptidase A.

Metal: Cu
Ligand type: Amino acid
Host protein: Carboxypeptidase A
Anchoring strategy: Metal substitution
Optimization: ---
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Oxidation of vitamin C