1 publication
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Creation of an Artificial Metalloprotein with a Hoveyda–Grubbs Catalyst Moiety through the Intrinsic Inhibition Mechanism of α-Chymotrypsin
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Chem. Commun. 2012, 48, 1662, 10.1039/c2cc16898g
An L-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda–Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein.
Metal: RuLigand type: CarbeneHost protein: α-chymotrypsinAnchoring strategy: CovalentOptimization: ---Notes: RCM
