Bimetallic Copper-Heme-Protein-DNA Hybrid Catalyst for Diels Alder Reaction
Croat. Chem. Acta 2011, 84, 269-275, 10.5562/cca1828
A bimetallic heme-DNA cofactor, containing an iron and a copper center, was synthesized for the design of novel hybrid catalysts for stereoselective synthesis. The cofactor was used for the reconstitution of apo-myoglobin. Both the cofactor alone and its myoglobin adduct were used to catalyze a model Diels Alder reaction. Stereoselectivity of this conversion was analyzed by chiral HPLC. Reactions carried out in the presence of myoglobin-heme-Cu-DNA catalyst showed greater product conversion and stereoselectivity than those carried out with the heme-Cu-DNA cofactor. This observation suggested that the protein shell plays a significant role in the catalytic conversion.
Metal: CuLigand type: BipyridineHost protein: Myoglobin (Mb)Anchoring strategy: SupramolecularOptimization: ---Reaction: Diels-Alder reactionMax TON: 7.1ee: 18PDB: ---Notes: Horse heart myoglobin