1 publication

1 publication

Enzyme stabilization via computationally guided protein stapling

Fasan, R.; Khare, S. D.

Proc. Natl. Acad. Sci. U. S. A., 2017, 10.1073/pnas.1708907114


Metal: Fe
Ligand type: Porphyrin
Host protein: Myoglobin (Mb)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: Cyclopropanation
Max TON: 4740
ee: 99.2
PDB: ---
Notes: Stapling of protein via thioether bond formation between the noncanonical amino acid O-2-bromoethyl tyrosine and cysteine