2 publications

2 publications

Studies on the Oxidase Activity of Copper (II) Carboxypeptidase A

Kaiser, E.T.

J. Chem. Soc., Chem. Commun. 1976, 830, 10.1039/C39760000830

Copper(II) carboxypeptidase A catalyses the oxidation of ascorbic acid and this reaction is inhibited by α-benzylsuccinate, a known inhibitor of the thiolesterase action of the copper enzyme; the pH dependencies of kcat and kcat/Km are similar near pH 7 to those seen for the peptidase and esterase activities of native carboxypeptidase A.

Metal: Cu
Ligand type: Amino acid
Host protein: Carboxypeptidase A
Anchoring strategy: Metal substitution
Optimization: ---
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Oxidation of vitamin C

The Bovine Serum Albumin-2-Phenylpropane-1,2-diolatodioxoosmium(VI) Complex as an Enantioselective Catalyst for cis-Hydroxylation of Alkenes

Kokubo, T.; Okano, M.

J. Chem. Soc., Chem. Commun. 1983, 0, 769-770, 10.1039/C39830000769

The 1:1 complex between an osmate ester and bovine serum albumin was found to be effective as an enantioselective catalyst in the cis-hydroxylation of alkenes, affording diols in up to 68% e.e. and turnover of the catalyst with t-butyl hydroperoxide.

Metal: Os
Ligand type: Undefined
Anchoring strategy: Undefined
Optimization: ---
Reaction: Dihydroxylation
Max TON: 40
ee: 68
PDB: ---
Notes: ---