Artificial Metalloenzymes Publications @Ward Group

Title
Date
Journal

1 publication

A "Broad Spectrum" Carbene Transferase for Synthesis of Chiral α-Trifluoromethylated Organoborons

ACS Cent. Sci. 2019, 5, 206-208, 10.1021/acscentsci.9b00015

Directed evolution generated an enzyme for the enantioselective synthesis of α-trifluoromethylated organoborons—potentially attractive synthons for fluorinated compounds.

Metal: Fe

Ligand type: Porphyrin

Host protein: Cytochrome c

Anchoring strategy: Native

Optimization: Genetic

Reaction: B-H insertion

Max TON: 2900

ee: 95

PDB: ---

Notes: ---