An Artificial Metalloenzyme for Carbene Transfer Based on a Biotinylated Dirhodium Anchored Within Streptavidin
We report an artificial carbenoid transferase which combines a biotinylated dirhodium moiety within streptavidin scaffold.
Metal: RhLigand type: CarboxylateHost protein: Streptavidin (Sav)Reaction: CyclopropanationMax TON: ~60ee: ---PDB: ---Notes: Cyclopropanation reaction was also performed in the E. coli periplasm.
Covalent Versus Non-covalent (Biocatalytic) Approaches for Enantioselective Sulfoxidation Catalyzed by Corrole Metal Complexes
Oxidation of thioanisoles, catalyzed by chiral manganese(III) and iron(III) corroles, provides the corresponding sulfoxides in moderate chemical yields and low enantioselectivities. Biocatalysis by non-chiral albumin-associated manganese(III) corroles proceeds much better and allows for the enantioselective synthesis of the pharmacologically important R-modafinil, in 88% yield and 73% ee.