A Cofactor Approach to Copper-Dependent Catalytic Antibodies
A Designed Supramolecular Protein Assembly with In Vivo Enzymatic Activity
A Highly Specific Metal-Activated Catalytic Antibody
Artificial Metalloenzymes based on Protein Cavities: Exploring the Effect of Altering the Metal Ligand Attachment Position by Site Directed Mutagenesis
A Semisynthetic Metalloenzyme based on a Protein Cavity that Catalyzes the Enantioselective Hydrolysis of Ester and Amide Substrates
Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering
Catalytic Properties and Specificity of the Extracellular Nuclease of Staphylococcus Aureus
Computational Redesign of a Mononuclear Zinc Metalloenzyme for Organophosphate Hydrolysis
Design and Evolution of New Catalytic Activity with an Existing Protein Scaffold
Engineered Metal Regulation of Trypsin Specificity
Generation of a Hybrid Sequence-Specific Single Stranded Deoxyribonuclease
Hydrolytic Catalysis and Structural Stabilization in a Designed Metalloprotein
Zn ion for catalytic activity, Hg ion for structural stability of the ArM. PDB ID 3PBJ = Structure of an analogue.
Zn ion for catalytic activity, Hg ion for structural stability of the ArM, kcat/KM ≈ 1.8*105 M-1*s-1. PDB ID 3PBJ = Structure of an analogue.
Influence of Active Site Location on Catalytic Activity in De Novo-Designed Zinc Metalloenzymes
Influence of position of Zn and Hg ion on catalytic activity of the ArM tested. PDB ID 3PBJ = Structure of an analogue.
Metal Ion Dependent Binding of Sulphonamide to Carbonic Anhydrase