1 publication

1 publication

Peroxidase Activity of an Antibody-Heme Complex

Schultz, P.G.

J. Am. Chem. Soc. 1990, 112, 9414-9415, 10.1021/ja00181a065

The specificity and diversity of the immune system have recently been exploited in the generation of antibodies that catalyze a wide variety of chemical reactions.1·2 Several general strategies for the design of catalytic antibodies have emerged, including the use of antibody binding energy to enhance the chemical reactivity of a cofactor or to position a cofactor and a substrate in close proximity.3,4 An intriguing target for antibody-cofactor catalysis is the oxidative reactions characteristic of heme proteins. Here we report that antibodies specific for A-methylmesoporphyrin IX bind iron(III) mesoporphyrin IX and that the resulting complex catalyzes the oxidation of several substrates. These studies are a first step toward the development of selective antibody-heme monooxygenase catalysts.

Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody7G12-A10-G1-A12
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: 200-500
ee: ---
PDB: ---
Notes: ---