398 publications

398 publications

(η6-Arene) Ruthenium(II) Complexes and Metallo-Papain Hybrid as Lewis Acid Catalysts of Diels–Alder Reaction in Water

Salmain, M.

Dalton Trans., 2010, 10.1039/c001630f

Covalent embedding of a (η6-arene) ruthenium(II) complex into the protein papain gives rise to a metalloenzyme displaying a catalytic efficiency for a Lewis acid-mediated catalysed Diels–Alder reaction enhanced by two orders of magnitude in water.


Metal: Ru
Ligand type: Benzene; Phenanthroline
Host protein: Papain (PAP)
Anchoring strategy: Covalent
Optimization: Chemical
Max TON: 440
ee: ---
PDB: ---
Notes: TOF = 220 h-1

X-Ray Structure and Designed Evolution of an Artificial Transfer Hydrogenase

Ward, T. R.

Angew. Chem., Int. Ed., 2008, 10.1002/anie.200704865


Metal: Ru
Ligand type: Amino-sulfonamide; Benzene
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: 100
ee: 92
PDB: 2QCB
Notes: ---

Metal: Ru
Ligand type: Amino-sulfonamide; P-cymene
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: 97
ee: 96
PDB: 2QCB
Notes: ---

Various Strategies for Obtaining Oxidative Artificial Hemoproteins with a Catalytic Oxidative Activity: From "Hemoabzymes" to "Hemozymes"?

Review

Mahy, J.-P.

J. Porphyr. Phthalocyanines, 2014, 10.1142/S1088424614500813


Notes: ---

Various Strategies for Obtaining Artificial Hemoproteins: From "Hemoabzymes" to "Hemozymes"

Mahy, J.-P.

Biochimie, 2009, 10.1016/j.biochi.2009.03.002


Metal: Fe
Ligand type: Porphyrin
Host protein: Xylanase A (XynA)
Anchoring strategy: Supramolecular
Optimization: Chemical
Reaction: Sulfoxidation
Max TON: ---
ee: 36
PDB: ---
Notes: ---

Vanadium-Catalysed Enantioselective Sulfoxidations: Rational Design of Biocatalytic and Biomimetic Systems

Sheldon, R. A.

Top. Catal., 2000, 10.1023/A:1009094619249


Metal: V
Ligand type: Oxide
Host protein: Phytase
Anchoring strategy: Undefined
Optimization: Chemical
Reaction: Sulfoxidation
Max TON: ---
ee: 68
PDB: ---
Notes: ---

Use of the Confined Spaces of Apo-Ferritin and Virus Capsids as Nanoreactors for Catalytic Reactions

Review

Ueno, T.

Curr. Opin. Chem. Biol., 2015, 10.1016/j.cbpa.2014.12.026


Notes: ---

Upregulation of an Artificial Zymogen by Proteolysis

Ward, T. R.

Angew. Chem., Int. Ed., 2016, 10.1002/anie.201605010


Metal: Ir
Ligand type: Cp*; Tripeptide
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: 2000
ee: 73
PDB: ---
Notes: ---

Transforming Carbonic Anhydrase into Epoxide Synthase by Metal Exchange

Soumillion, P.

ChemBioChem, 2006, 10.1002/cbic.200600127


Metal: Mn
Ligand type: Amino acid
Anchoring strategy: Metal substitution
Optimization: Chemical & genetic
Reaction: Epoxidation
Max TON: 4.1
ee: 52
PDB: ---
Notes: ---

Metal: Mn
Ligand type: Amino acid
Anchoring strategy: Metal substitution
Optimization: Chemical & genetic
Reaction: Epoxidation
Max TON: 10.3
ee: 40
PDB: ---
Notes: ---

Toward the Computational Design of Artificial Metalloenzymes: From Protein–Ligand Docking to Multiscale Approaches

Review

Maréchal, J.-D.

ACS Catal., 2015, 10.1021/acscatal.5b00010


Notes: ---

Towards the Directed Evolution of Hybrid Catalysts

Reetz, M. T.

Chimia, 2002, 10.2533/000942902777679920


Metal: Mn
Ligand type: Salen
Host protein: Papain (PAP)
Anchoring strategy: Covalent
Optimization: ---
Reaction: Epoxidation
Max TON: ---
ee: < 10
PDB: ---
Notes: ---

Metal: Rh
Ligand type: Dipyridin-2-ylmethane
Host protein: Papain (PAP)
Anchoring strategy: Covalent
Optimization: ---
Reaction: Hydrogenation
Max TON: ---
ee: < 10
PDB: ---
Notes: ---

Towards Evolution of Artificial Metalloenzymes - A Protein Engineer’s Perspective

Review

Schwaneberg, U.

Angew. Chem., Int. Ed., 2018, 10.1002/anie.201811042


Notes: ---

Towards Antibody-Mediated Metallo-Porphyrin Chemistry

Keinan, E.

Pure Appl. Chem., 1990, 10.1351/pac199062102013


Metal: Mn
Ligand type: Porphyrin
Host protein: Antibody
Anchoring strategy: Supramolecular
Optimization: ---
Max TON: 549
ee: ---
PDB: ---
Notes: ---

Thermostable Peroxidase-Activity with a Recombinant Antibody L-Chain-Porphyrin Fe(III) Complex

Imanaka, T.

FEBS Lett., 1995, 10.1016/0014-5793(95)01224-3


Metal: Fe
Ligand type: Porphyrin
Anchoring strategy: Antibody
Optimization: ---
Reaction: Peroxidation
Max TON: ---
ee: ---
PDB: ---
Notes: ---

The Rational Design of Semisynthetic Peroxidases

Sheldon, R. A.

Biotechnol. Bioeng., 2000, 10.1002/(SICI)1097-0290(20000105)67:1<87::AID-BIT10>3.0.CO;2-8


Metal: V
Ligand type: Oxide
Host protein: Phytase
Anchoring strategy: Undefined
Optimization: Chemical
Reaction: Sulfoxidation
Max TON: ---
ee: 66
PDB: ---
Notes: Reaction performed in 30% organic co-solvent.

The Protein Environment Drives Selectivity for Sulfide Oxidation by an Artificial Metalloenzyme

Cavazza, C.; Ménage, S.

ChemBioChem, 2009, 10.1002/cbic.200800595


Metal: Mn
Ligand type: Salen
Anchoring strategy: Supramolecular
Optimization: Chemical
Reaction: Sulfoxidation
Max TON: 97
ee: ---
PDB: ---
Notes: ---

The Plasticity of Redox Cofactors: From Metalloenzymes to Redox-Active DNA

Review

Happe, T.; Hemschemeier, A.

Nat. Rev. Chem., 2018, 10.1038/s41570-018-0029-3


Notes: ---

The Important Role of Covalent Anchor Positions in Tuning Catalytic Properties of a Rationally Designed MnSalen-Containing Metalloenzyme

Lu, Y.; Zhang, J.-L.

ACS Catal., 2011, 10.1021/cs200258e


Metal: Mn
Ligand type: Salen
Host protein: Myoglobin (Mb)
Anchoring strategy: Covalent
Optimization: Genetic
Reaction: Sulfoxidation
Max TON: ---
ee: 83
PDB: ---
Notes: Reaction rate: 2.3 min-1

The Bovine Serum Albumin-2-Phenylpropane-1,2-diolatodioxoosmium(VI) Complex as an Enantioselective Catalyst for cis-Hydroxylation of Alkenes

Kokubo, T.; Okano, M.

J. Chem. Soc., Chem. Commun., 1983, 10.1039/C39830000769


Metal: Os
Ligand type: Undefined
Anchoring strategy: Undefined
Optimization: ---
Reaction: Dihydroxylation
Max TON: 40
ee: 68
PDB: ---
Notes: ---

The Ascent of Man(Made Oxidoreductases)

Review

Anderson, J. L. R.

Curr. Opin. Struct. Biol., 2018, 10.1016/j.sbi.2018.04.008


Notes: ---

Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology

Ward, T. R.

Angew. Chem., Int. Ed., 2005, 10.1002/anie.200502000


Metal: Rh
Ligand type: Phosphine
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: Hydrogenation
Max TON: ---
ee: 94
PDB: ---
Notes: ---

Systematic Tuning of Heme Redox Potentials and Its Effects on O2 Reduction Rates in a Designed Oxidase in Myoglobin

Lu, Y.

J. Am. Chem. Soc., 2014, 10.1021/ja5054863


Metal: Cu
Ligand type: Amino acid
Host protein: Myoglobin (Mb)
Anchoring strategy: Dative
Optimization: Chemical & genetic
Max TON: 1600
ee: ---
PDB: 4FWX
Notes: Sperm whale myoglobin

Synthetic Cascades are Enabled by Combining Biocatalysts with Artificial Metalloenzymes

Turner, N. J.; Ward, T. R.

Nat. Chem., 2013, 10.1038/NCHEM.1498


Metal: Ir
Ligand type: Amino-sulfonamide; Cp*
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Genetic
Max TON: 100
ee: > 99
PDB: ---
Notes: Cascade

Synthesis of Hybrid Transition-Metalloproteins via Thiol-Selective Covalent Anchoring of Rh-Phosphine and Ru-Phenanthroline Complexes

Kamer, P. C. J.; Laan, W.

Dalton Trans., 2010, 10.1039/c0dt00239a


Metal: Rh
Ligand type: COD; Phosphine
Anchoring strategy: Covalent
Optimization: ---
Reaction: Hydrogenation
Max TON: ---
ee: ---
PDB: 2PHY
Notes: ---

Synthesis of a Sequence-Specific DNA-Cleaving Peptide

Dervan, P. B.

Science, 1987, 10.1126/science.3120311


Metal: Fe
Ligand type: EDTA
Anchoring strategy: Covalent
Optimization: ---
Reaction: DNA cleavage
Max TON: <1
ee: ---
PDB: ---
Notes: Engineered sequence specificity

Synthesis of a New Estradiol–Iron Metalloporphyrin Conjugate Used to Build up a New Hybrid Biocatalyst for Selective Oxidations by the ‘Trojan Horse’ Strategy

Mahy, J.-P.

Tetrahedron Lett., 2008, 10.1016/j.tetlet.2008.01.022


Metal: Fe
Ligand type: Porphyrin
Host protein: Antibody 7A3
Anchoring strategy: Supramolecular
Optimization: ---
Reaction: Sulfoxidation
Max TON: 12
ee: 8
PDB: ---
Notes: ---

Synthesis of a Heterogeneous Artificial Metallolipase with Chimeric Catalytic Activity

Filice, M.

Chem. Commun., 2015, 10.1039/C5CC02450A


Metal: Cu
Ligand type: Phenanthroline
Anchoring strategy: Covalent
Optimization: Genetic
Max TON: 411
ee: 92
PDB: ---
Notes: ArM is immobilized on Sepabeads. Endo/exo = 93.5%

Metal: Cu
Ligand type: Phenanthroline
Anchoring strategy: Covalent
Optimization: Genetic
Reaction: Reduction
Max TON: ---
ee: ---
PDB: ---
Notes: Cascade reaction: Ester hydrolysis (natural function of the host protein) followed by reduction (function of the designed ArM).

Supramolecular Interactions Between Functional Metal Complexes and Proteins

Review

Duhme-Klair, A. K.

Dalton Trans., 2009, 10.1039/b915776j


Notes: ---

Supramolecular Enzyme Mimics

Review

Okamoto, Y.; Ward, T. R.

Comprehensive Supramolecular Chemistry II, 2017, 10.1016/B978-0-12-409547-2.12551-X


Notes: Book chapter

Supramolecular Assembly of Artificial Metalloenzymes Based on the Dimeric Protein LmrR as Promiscuous Scaffold

Roelfes, G.

J. Am. Chem. Soc., 2015, 10.1021/jacs.5b05790


Metal: Cu
Ligand type: Phenanthroline
Host protein: LmrR
Anchoring strategy: Supramolecular
Optimization: Genetic
Max TON: 11.1
ee: 94
PDB: 3F8B
Notes: ---

Supramolecular Anchoring of NCN-Pincer Palladium Complexes into a β-Barrel Protein Host: Molecular-Docking and Reactivity Insights

Salmain, M.; Thorimbert, S.

Eur. J. Inorg. Chem., 2017, 10.1002/ejic.201700365


Metal: Pd
Ligand type: NCN-Pincer (amines)
Host protein: β-lactoglobulin (βLG)
Anchoring strategy: Supramolecular
Optimization: Chemical
Reaction: Aldol condensation
Max TON: 4.9
ee: 0
PDB: ---
Notes: Aldol condensation of methyl isocyanoacetate and benzaldehyde (trans/cis = 38:62)