8 publications

8 publications

An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein

Reetz, M. T.

Angew. Chem., Int. Ed., 2010, 10.1002/anie.201002106

Guided by nature: A designed binding site comprising the His/His/Asp motif for CuII complexation has been constructed in a robust protein by site‐specific mutagenesis (see picture). The artificial metalloenzyme catalyzes an enantioselective Diels–Alder reaction.


Metal: Cu
Ligand type: Amino acid
Host protein: tHisF
Anchoring strategy: Dative
Optimization: Genetic
Max TON: 6.7
ee: 46
PDB: ---
Notes: ---

Artificial Metalloenzymes as Catalysts in Stereoselective Diels–Alder Reactions

Review

Reetz, M. T.

Chem. Rec., 2012, 10.1002/tcr.201100043


Notes: ---

Copper–Phthalocyanine Conjugates of Serum Albumins as Enantioselective Catalysts in Diels–Alder Reactions

Reetz, M. T.

Angew. Chem., Int. Ed., 2005, 10.1002/anie.200504561


Metal: Cu
Ligand type: Phthalocyanine
Anchoring strategy: Supramolecular
Optimization: Chemical
Max TON: 45.5
ee: 98
PDB: ---
Notes: ---

Directed Evolution of Artificial Metalloenzymes

Review

Reetz, M. T.

Isr. J. Chem., 2015, 10.1002/ijch.201400087


Notes: ---

Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts?

Review

Reetz, M. T.

Acc. Chem. Res., 2019, 10.1021/acs.accounts.8b00582


Notes: ---

Directed Evolution of Hybrid Enzymes: Evolving Enantioselectivity of an Achiral Rh-Complex Anchored to a Protein

Reetz, M. T.

Chem. Commun., 2006, 10.1039/b610461d


Metal: Rh
Ligand type: COD; Phosphine
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Genetic
Reaction: Hydrogenation
Max TON: 4500
ee: 65
PDB: ---
Notes: ---

Directed Evolution of Stereoselective Hybrid Catalysts

Review

Reetz, M. T.

Top. Organomet. Chem., 2009, 10.1007/3418_2008_12


Notes: ---

Towards the Directed Evolution of Hybrid Catalysts

Reetz, M. T.

Chimia, 2002, 10.2533/000942902777679920


Metal: Mn
Ligand type: Salen
Host protein: Papain (PAP)
Anchoring strategy: Covalent
Optimization: ---
Reaction: Epoxidation
Max TON: ---
ee: < 10
PDB: ---
Notes: ---

Metal: Rh
Ligand type: Dipyridin-2-ylmethane
Host protein: Papain (PAP)
Anchoring strategy: Covalent
Optimization: ---
Reaction: Hydrogenation
Max TON: ---
ee: < 10
PDB: ---
Notes: ---