3 publications

3 publications

Enzyme stabilization via computationally guided protein stapling

Fasan, R.; Khare, S. D.

Proc. Natl. Acad. Sci. U. S. A., 2017, 10.1073/pnas.1708907114


Metal: Fe
Ligand type: Porphyrin
Host protein: Myoglobin (Mb)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: Cyclopropanation
Max TON: 4740
ee: 99.2
PDB: ---
Notes: Stapling of protein via thioether bond formation between the noncanonical amino acid O-2-bromoethyl tyrosine and cysteine

Exploiting and Engineering Hemoproteins for Abiological Carbene and Nitrene Transfer Reactions

Review

Arnold, F. H.; Fasan, R.

Curr. Opin. Biotechnol., 2017, 10.1016/j.copbio.2017.06.005


Notes: ---

Intramolecular C(sp3)-H Amination of Arylsulfonyl Azides with Engineered and Artificial Myoglobin-Based Catalysts

Fasan, R.

Bioorg. Med. Chem., 2014, 10.1016/j.bmc.2014.05.015


Metal: Mn
Ligand type: Amino acid; Porphyrin
Host protein: Myoglobin (Mb)
Anchoring strategy: Metal substitution
Optimization: Chemical & genetic
Reaction: C-H activation
Max TON: 142
ee: ---
PDB: ---
Notes: ---