A Palladium-Catalyst Stabilized in the Chiral Environment of a Monoclonal Antibody in Water
Chem. Commun. 2020, 56, 1605-1607, 10.1039/c9cc08756g
We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst of the Pd-complex with mAb selectively gives the (R)-enantiomer product.
Metal: PdHost protein: AntibodyAnchoring strategy: SupramolecularOptimization: ---Reaction: Allylic aminationMax TON: 600ee: 98PDB: ---Notes: Recalculated TON