Artificial Metalloenzymes Publications @Ward Group

Title
Date
Journal

1 publication

Copper–Phthalocyanine Conjugates of Serum Albumins as Enantioselective Catalysts in Diels–Alder Reactions

Angew. Chem. Int. Ed. 2006, 45, 2416-2419, 10.1002/anie.200504561

Chirality from blood: Serum albumins form strong complexes with CuII–phthalocyanines, leading to protein conjugates. These hybrid catalysts promote enantioselective Diels–Alder reactions, such as that of azachalcones 1 with cyclopentadiene (2) to give products 3 with 85–98 % ee.

Metal: Cu

Ligand type: Phthalocyanine

Host protein: Bovine serum albumin (BSA)

Anchoring strategy: Supramolecular

Optimization: Chemical

Reaction: Diels-Alder reaction

Max TON: 45.5

ee: 98

PDB: ---

Notes: Chirality from blood: Serum albumins form strong complexes with CuII–phthalocyanines, leading to protein conjugates. These hybrid catalysts promote enantioselective Diels–Alder reactions, such as that of azachalcones 1 with cyclopentadiene (2) to give products 3 with 85–98 % ee.