2 publications

2 publications

Capture and Characterization of a Reactive Haem– Carbenoid Complex in an Artificial Metalloenzyme

Hilvert, D.

Nat. Catal., 2018, 10.1038/s41929-018-0105-6


Metal: Fe
Host protein: Myoglobin (Mb)
Anchoring strategy: ---
Optimization: Genetic
Reaction: Cyclopropanation
Max TON: 1000
ee: 99
PDB: 6F17
Notes: Structure of the Mb*(NMH) haem-iron complex

Metal: Fe
Host protein: Myoglobin (Mb)
Anchoring strategy: ---
Optimization: Genetic
Reaction: Cyclopropanation
Max TON: 1000
ee: 99
PDB: 6G5B
Notes: Structure of the Mb*(NMH) haem-iron–carbenoid complex

Redox-Switchable Siderophore Anchor Enables Reversible Artificial Metalloenzyme Assembly

Duhme-Klair, A. K.; Wilson, K. S.

Nat. Catal., 2018, 10.1038/s41929-018-0124-3


Metal: Ir
Ligand type: Cp*; Pyridine sulfonamide
Host protein: CeuE
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: ---
ee: 35.4
PDB: 5OD5
Notes: Redox switchable iron(III)-azotochelin anchor