1 publication
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Aqueous Oxidation of Alcohols Catalyzed by Artificial Metalloenzymes Based on the Biotin–Avidin Technology
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J. Organomet. Chem. 2005, 690, 4488-4491, 10.1016/j.jorganchem.2005.02.001
Based on the incorporation of biotinylated organometallic catalyst precursors within (strept)avidin, we have developed artificial metalloenzymes for the oxidation of secondary alcohols using tert-butylhydroperoxide as oxidizing agent. In the presence of avidin as host protein, the biotinylated aminosulfonamide ruthenium piano stool complex 1 (0.4 mol%) catalyzes the oxidation of sec-phenethyl alcohol at room temperature within 90 h in over 90% yield. Gel electrophoretic analysis of the reaction mixture suggests that the host protein is not oxidatively degraded during catalysis.
Metal: RuHost protein: Streptavidin (Sav)Anchoring strategy: SupramolecularOptimization: Chemical & geneticNotes: ---
Metal: RuHost protein: Avidin (Av)Anchoring strategy: SupramolecularOptimization: Chemical & geneticNotes: ---
Metal: RuHost protein: Streptavidin (Sav)Anchoring strategy: SupramolecularOptimization: Chemical & geneticNotes: ---
Metal: RhHost protein: Streptavidin (Sav)Anchoring strategy: SupramolecularOptimization: Chemical & geneticNotes: ---
Metal: IrHost protein: Streptavidin (Sav)Anchoring strategy: SupramolecularOptimization: Chemical & geneticNotes: ---