Structural Basis for Enantioselectivity in the Transfer Hydrogenation of a Ketone Catalyzed by an Artificial Metalloenzyme
Eur. J. Inorg. Chem. 2013, 2013, 3596-3600, 10.1002/ejic.201300592
The crystal structure of bovine β‐lactoglobulin bound to a complex consisting of a (η5‐Cp*)Rh(2,2′‐dipyridylamine) head and a lauric acid derived hydrophobic tail has been solved at 1.85 Å resolution. Previous work has shown that this hybrid catalyzes the transfer hydrogenation of an aryl ketone in neat water with formate as hydrogen donor with enantiomeric excess (ee) of about 26 %. Calculations using the X‐ray model indicate that the complex head can adopt discrete conformations, which may explain the ee observed.
Metal: RhLigand type: 2,2'-Dipyridylamine; Cp*Host protein: Bovine β-lactoglobulin (βLG)Anchoring strategy: SupramolecularOptimization: ---Reaction: Transfer hydrogenationMax TON: ---ee: 26PDB: 4KIINotes: ---