1 publication

1 publication

Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex

Harada, A.

Org. Biomol. Chem. 2006, 4, 3571, 10.1039/B609242J

Monoclonal antibodies have been elicited against an achiral rhodium complex and this complex was used in the presence of a resultant antibody, 1G8, for the catalytic hydrogenation of 2-acetamidoacrylic acid to produce N-acetyl-L-alanine in high (>98%) enantiomeric excess.

Metal: Rh
Ligand type: COD; Phosphine
Host protein: Antibody 1G8
Anchoring strategy: Antibody
Optimization: ---
Reaction: Hydrogenation
Max TON: ---
ee: ---
PDB: ---
Notes: ---