Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex
Org. Biomol. Chem. 2006, 4, 3571, 10.1039/B609242J
Monoclonal antibodies have been elicited against an achiral rhodium complex and this complex was used in the presence of a resultant antibody, 1G8, for the catalytic hydrogenation of 2-acetamidoacrylic acid to produce N-acetyl-L-alanine in high (>98%) enantiomeric excess.
Metal: RhHost protein: Antibody 1G8Anchoring strategy: AntibodyOptimization: ---Reaction: HydrogenationMax TON: ---ee: ---PDB: ---Notes: ---