9 publications

9 publications

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Green, A. P.; Hilvert, D.

J. Am. Chem. Soc., 2018, 10.1021/jacs.7b12621


Metal: Fe
Host protein: Myoglobin (Mb)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: Oxidation
Max TON: ~1650
ee: ---
PDB: 5OJ9
Notes: Oxidation of amplex red

Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials

Lombardi, A.; Nastri, F.

Int. J. Mol. Sci., 2018, 10.3390/ijms19102896


Metal: Fe
Ligand type: Amino acid; Porphyrin
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Immobilization of the ArM on gold surfaces via a lipoic acid anchor.

Autoxidation of Ascorbic Acid Catalyzed by a Semisynthetic Enzyme

Kaiser, E. T.

Biopolymers, 1990, 10.1002/bip.360290107


Metal: Cu
Ligand type: Bipyridine
Host protein: Papain (PAP)
Anchoring strategy: Covalent
Optimization: ---
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: ---

Building Reactive Copper Centers in Human Carbonic Anhydrase II

Emerson, J. P.

J. Biol. Inorg. Chem., 2013, 10.1007/s00775-013-1009-1


Metal: Cu
Ligand type: Amino acid
Anchoring strategy: Dative
Optimization: ---
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: 1RZC
Notes: Oxidation of 2-aminophenol with subsequent formation of 2-aminophenoxazinone. Reaction rate = 0.09 s-1

Construction and In Vivo Assembly of a Catalytically Proficient and Hyperthermostable De Novo Enzyme

Anderson, J. L. R.

Nat. Commun., 2017, 10.1038/s41467-017-00541-4


Metal: Fe
Ligand type: Porphyrin
Anchoring strategy: Supramolecular
Optimization: Genetic
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Oxidation of 2,2′-azino-bis(3-ethylbenzothiazo-line-6-sulfonic acid (ABTS)

Metal Incorporated Horseradish Peroxidase (HRP) Catalyzed Oxidation of Resveratrol: Selective Dimerization or Decomposition

Pan, Y.

RSC Adv., 2013, 10.1039/c3ra43784a


Metal: Ca; Co; Mn; Ni; Zn
Ligand type: Undefined
Anchoring strategy: Undefined
Optimization: Chemical
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Oxidation of resveratrol. Dimerisation product obtained.

Multifunctional Nanoenzymes from Carbonic Anhydrase Skeleton

Yilmaz, F.

Process Biochem., 2018, 10.1016/j.procbio.2018.06.005


Metal: Zn
Ligand type: Amino acid
Host protein: Carbonic anhydrase (CA)
Anchoring strategy: Metal substitution
Optimization: Chemical
Reaction: Hydrolysis
Max TON: ---
ee: ---
PDB: ---
Notes: Cross-linked carbonic anhydrase nano-enzyme particles (93 nm in diameter). Hydrolysis of 4-nitrophenyl acetate.

Metal: Rh
Ligand type: Amino acid
Host protein: Carbonic anhydrase (CA)
Anchoring strategy: Metal substitution
Optimization: Chemical
Reaction: Hydration
Max TON: ---
ee: ---
PDB: ---
Notes: Cross-linked carbonic anhydrase nano-enzyme particles (93 nm in diameter). Hydration of styrene.

Metal: Mn
Ligand type: Amino acid
Host protein: Carbonic anhydrase (CA)
Anchoring strategy: Metal substitution
Optimization: Chemical
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Cross-linked carbonic anhydrase nano-enzyme particles (93 nm in diameter). Oxidation of styrene.

Peroxide Activation Regulated by Hydrogen Bonds within Artificial Cu Proteins

Borovik, A. S.

J. Am. Chem. Soc., 2017, 10.1021/jacs.7b10452


Metal: Cu
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: 6ANX
Notes: ---

Studies on the Oxidase Activity of Copper (II) Carboxypeptidase A

Kaiser, E. T.

J. Chem. Soc., Chem. Commun., 1976, 10.1039/C39760000830


Metal: Cu
Ligand type: Amino acid
Host protein: Carboxypeptidase A
Anchoring strategy: Metal substitution
Optimization: ---
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Oxidation of vitamin C