Export
Export the current list as a CSV file
Abstracts
Show/hide abstracts
6 publications
Sort by Titlearrow_drop_down Datearrow_drop_down Journalarrow_drop_downA Highly Active Biohybrid Catalyst for Olefin Metathesis in Water: Impact of a Hydrophobic Cavity in a β-Barrel Protein
A series of Grubbs–Hoveyda type catalyst precursors for olefin metathesis containing a maleimide moiety in the backbone of the NHC ligand was covalently incorporated in the cavity of the β-barrel protein nitrobindin. By using two protein mutants with different cavity sizes and choosing the suitable spacer length, an artificial metalloenzyme for olefin metathesis reactions in water in the absence of any organic cosolvents was obtained. High efficiencies reaching TON > 9000 in the ROMP of a water-soluble 7-oxanorbornene derivative and TON > 100 in ring-closing metathesis (RCM) of 4,4-bis(hydroxymethyl)-1,6-heptadiene in water under relatively mild conditions (pH 6, T = 25–40 °C) were observed.
Metal:
Ligand type:
Host protein:
Anchoring strategy:
Optimization:
Notes:
ROMP (cis/trans: 48/52)
Metal:
Ligand type:
Host protein:
Anchoring strategy:
Optimization:
Notes:
RCM
A Hybrid Ring- Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the Beta-Barrel Protein FhuA
A β‐barrel protein hybrid catalyst was prepared by covalently anchoring a Grubbs–Hoveyda type olefin metathesis catalyst at a single accessible cysteine amino acid in the barrel interior of a variant of β‐barrel transmembrane protein ferric hydroxamate uptake protein component A (FhuA). Activity of this hybrid catalyst type was demonstrated by ring‐opening metathesis polymerization of a 7‐oxanorbornene derivative in aqueous solution.
Metal:
Ligand type:
Host protein:
Anchoring strategy:
Optimization:
Notes:
ROMP
Artificial Diels–Alderase based on the Transmembrane Protein FhuA
Metal:
Ligand type:
Host protein:
Anchoring strategy:
Optimization:
Notes:
---
Hybrid Ruthenium ROMP Catalysts Based on an Engineered Variant of β-Barrel Protein FhuA ΔCVFtev: Effect of Spacer Length
Metal:
Ligand type:
Host protein:
Anchoring strategy:
Optimization:
Notes:
ROMP; cis/trans = 58/42
Metatheases: Artificial Metalloproteins for Olefin Metathesis
ReviewNotes:
---
Olefin Metathesis Catalysts Embedded in β-Barrel Proteins: Creating Artificial Metalloproteins for Olefin Metathesis
ReviewNotes:
---