4 publications

4 publications

Albumin as a Promiscuous Biocatalyst in Organic Synthesis

Review

Gaggero, N.

RSC Adv. 2015, 5, 10588-10598, 10.1039/C4RA11206G

Albumin emerged as a biocatalyst in 1980 and the continuing interest in this protein is proved by numerous papers.


Notes: ---

Asymmetric Catalytic Sulfoxidation by a Novel VIV8 Cluster Catalyst in the Presence of Serum Albumin: A Simple and Green Oxidation System

Bian, H.-D.; Huang, F.-P.

RSC Adv. 2016, 6, 44154-44162, 10.1039/C6RA08153C

Enantioselective oxidation of a series of alkyl aryl sulfides catalyzed by a novel VIV8 cluster is tested in an aqueous medium in the presence of serum albumin. The procedure is simple, environmentally friendly, selective, and highly reactive.


Metal: V
Anchoring strategy: Undefined
Optimization: Chemical
Reaction: Sulfoxidation
Max TON: 140
ee: 77
PDB: ---
Notes: Screening with different serum albumins.

Highly Malleable Harm-Binding Site of the Haemoprotein HasA Permits Stable Accommodation of Bulky Tetraphenylporphycenes

Shoji, O.

RSC Adv. 2019, 9, 18697-18702, 10.1039/c9ra02872b

Iron(III)- and cobalt(III)-9,10,19,20-tetraphenylporphycenes, which possess bulky phenyl groups at the four meso positions of porphycene, were successfully incorporated into the haem acquisition protein HasA secreted by Pseudomonas aeruginosa. Crystal structure analysis revealed that loops surrounding the haem-binding site are highly flexible, remodelling themselves to accommodate bulky metal complexes with significantly different structures from the native haem cofactor.


Metal: Co; Fe
Ligand type: Porphycene
Host protein: HasA
Anchoring strategy: Dative
Optimization: Chemical & genetic
Reaction: ---
Max TON: ---
ee: ---
PDB: ---
Notes: ---

Metal Incorporated Horseradish Peroxidase (HRP) Catalyzed Oxidation of Resveratrol: Selective Dimerization or Decomposition

Pan, Y.

RSC Adv. 2013, 3, 22976, 10.1039/c3ra43784a

Horseradish Peroxidase (HRP) is a commercially available and prevalently used peroxidase with no specific substrate binding domain. However, after being incorporated with different metal cations, new catalytic functions were found in biomimetic oxidation of resveratrol. Based on the results of screening, Ca, Cu, Fe and Mn incorporated enzymes showed distinctive effects, either decomposition or dimerization products were observed.


Metal: Ca; Co; Mn; Ni; Zn
Ligand type: Undefined
Anchoring strategy: Undefined
Optimization: Chemical
Reaction: Oxidation
Max TON: ---
ee: ---
PDB: ---
Notes: Oxidation of resveratrol. Dimerisation product obtained.