2 publications

2 publications

Preparation of an Immobilized Lipase-Palladium Artificial Metalloenzyme as Catalyst in the Heck Reaction: Role of the Solid Phase

Filice, M.; Palomo, J.M.

Adv. Synth. Catal., 2015, 10.1002/adsc.201500014


Metal: Pd
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Max TON: ~4160
ee: 96
PDB: ---
Notes: ArM is immobilized on Sepabeads.

Synthesis of a Heterogeneous Artificial Metallolipase with Chimeric Catalytic Activity

Filice, M.

Chem. Commun., 2015, 10.1039/C5CC02450A


Metal: Cu
Ligand type: Phenanthroline
Anchoring strategy: Covalent
Optimization: Genetic
Max TON: 411
ee: 92
PDB: ---
Notes: ArM is immobilized on Sepabeads. Endo/exo = 93.5%

Metal: Cu
Ligand type: Phenanthroline
Anchoring strategy: Covalent
Optimization: Genetic
Reaction: Reduction
Max TON: ---
ee: ---
PDB: ---
Notes: Cascade reaction: Ester hydrolysis (natural function of the host protein) followed by reduction (function of the designed ArM).