Chem. Sci. 2016, 7, 959-968, 10.1039/C5SC03397G
Crystal structures of semisynthetic [FeFe]-hydrogenases with variations in the [2Fe] cluster show little structural differences despite strong effects on activity.
Dalton Trans. 2017, 46, 16947-16958, 10.1039/C7DT03785F
Combination of biological and chemical methods allow for creation of [FeFe]-hydrogenases with an artificial synthetic cofactor.