An Enantioselective Artificial Suzukiase Based on the Biotin–Streptavidin Technology
Introduction of a biotinylated monophosphine palladium complex within streptavidin affords an enantioselective artificial Suzukiase. Site-directed mutagenesis allowed the optimization of the activity and the enantioselectivity of this artificial metalloenzyme. A variety of atropisomeric biaryls were produced in good yields and up to 90% ee.
Metal: PdHost protein: Streptavidin (Sav)Anchoring strategy: SupramolecularOptimization: Chemical & geneticReaction: Suzuki cross-couplingMax TON: 88ee: 80PDB: ---Notes: ---