1 publication

1 publication

Metal-Assembled Modular Proteins: Toward Functional Protein Design


Case, M.A.

Acc. Chem. Res. 2004, 10.1021/ar960245+

Metal-assembled parallel helix-bundle proteins have been used to investigate electron transfer through α-helical structures. Fermi Golden Rule distance dependence of electron transfer rates was established in a family of designed metalloproteins, and the contribution of intrahelical hydrogen bonding to the matrix tunneling element was explored. The first steps toward the design of functional proteins using dynamic combinatorial assembly of α-helical structural elements are described.

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