4 publications

4 publications

Chemical Conversion of a DNA-Binding Protein into a Site-Specific Nuclease

Sigman, D. S.

Science, 1987, 10.1126/science.2820056


Metal: Cu
Ligand type: Phenanthroline
Anchoring strategy: Covalent
Optimization: ---
Reaction: Oxidative cleavage
Max TON: <1
ee: ---
PDB: ---
Notes: Engineered sequence specificity

Flavohemoglobin: A Semisynthetic Hydroxylase Acting in the Absence of Reductase

Kaiser, E. T.

J. Am. Chem. Soc., 1987, 10.1021/ja00236a062


Metal: Fe
Ligand type: Porphyrin
Host protein: Hemoglobin
Anchoring strategy: ---
Optimization: ---
Max TON: ---
ee: ---
PDB: ---
Notes: ---

Generation of a Hybrid Sequence-Specific Single Stranded Deoxyribonuclease

Schultz, P. G.

Science, 1987, 10.1126/science.3685986


Metal: Ca
Ligand type: Undefined
Host protein: Staphylococcal nuclease
Anchoring strategy: ---
Optimization: ---
Max TON: <1
ee: ---
PDB: ---
Notes: Engineered sequence specificity

Synthesis of a Sequence-Specific DNA-Cleaving Peptide

Dervan, P. B.

Science, 1987, 10.1126/science.3120311


Metal: Fe
Ligand type: EDTA
Anchoring strategy: Covalent
Optimization: ---
Reaction: DNA cleavage
Max TON: <1
ee: ---
PDB: ---
Notes: Engineered sequence specificity