18 publications

18 publications

A Hydrogenase Model System Based on the Sequence of Cytochrome c: Photochemical Hydrogen Evolution in Aqueous Media

Hayashi, T

Chem. Commun., 2011, 10.1039/c1cc11157d

The diiron carbonyl cluster is held by a native CXXC motif, which includes Cys14 and Cys17, in the cytochrome c sequence. It is found that the diiron carbonyl complex works well as a catalyst for H2 evolution. It has a TON of ∼80 over 2 h at pH 4.7 in the presence of a Ru-photosensitizer and ascorbate as a sacrificial reagent in aqueous media.


Metal: Fe
Ligand type: Carbonyl
Host protein: Cytochrome c
Anchoring strategy: Dative
Optimization: ---
Reaction: H2 evolution
Max TON: 82
ee: ---
PDB: ---
Notes: Horse heart cytochrome C

Aqueous Light Driven Hydrogen Production by a Ru–Ferredoxin–Co Biohybrid

Utschig, L. M.

Chem. Commun., 2015, 10.1039/c5cc03006d


Metal: Co
Ligand type: Oxime
Host protein: Ferredoxin (Fd)
Anchoring strategy: Dative
Optimization: ---
Reaction: H2 evolution
Max TON: 210
ee: ---
PDB: ---
Notes: Recalculated TON

Artificial Hydrogenases Based on Cobaloximes and Heme Oxygenase

Artero, V.

ChemPlusChem, 2016, 10.1002/cplu.201600218


Metal: Co
Ligand type: Oxime
Host protein: Heme oxygenase (HO)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: H2 evolution
Max TON: 15.3
ee: ---
PDB: ---
Notes: ---

A Structural View of Synthetic Cofactor Integration into [FeFe]-Hydrogenases

Apfel, U.-P.; Happe, T.; Kurisu, G.

Chem. Sci., 2016, 10.1039/C5SC03397G


Metal: Fe
Ligand type: CN; CO; Dithiolate
Anchoring strategy: Dative
Optimization: Chemical
Reaction: H2 evolution
Max TON: ---
ee: ---
PDB: 4XDC
Notes: H2 evolution activity of the ArM: 2874 (mmol H2)*min-1*(mg protein)-1.

Chalcogenide Substitution in the [2Fe] Cluster of [FeFe]-Hydrogenases Conserves High Enzymatic Activity

Apfel, U.-P.; Happe, T.

Dalton Trans., 2017, 10.1039/C7DT03785F


Metal: Fe
Ligand type: CN; CO; Diselenolate
Anchoring strategy: Dative
Optimization: Chemical
Reaction: H2 evolution
Max TON: ---
ee: ---
PDB: 5OEF
Notes: ---

Cobaloxime-Based Artificial Hydrogenase

Artero, V.

Inorg. Chem., 2014, 10.1021/ic501014c


Metal: Co
Ligand type: Oxime
Host protein: Myoglobin (Mb)
Anchoring strategy: Supramolecular
Optimization: Chemical
Reaction: H2 evolution
Max TON: 5
ee: ---
PDB: ---
Notes: Sperm whale myoglobin

Generation of a Functional, Semisynthetic [FeFe]-Hydrogenase in a Photosynthetic Microorganism

Berggren, G.; Lindblad, P.

Energy Environ. Sci., 2018, 10.1039/C8EE01975D


Metal: Fe
Ligand type: CN; CO
Anchoring strategy: Reconstitution
Optimization: Chemical & genetic
Reaction: H2 evolution
Max TON: ---
ee: ---
PDB: ---
Notes: ---

Going Beyond Structure: Nickel-Substituted Rubredoxin as a Mechanistic Model for the [NiFe] Hydrogenases

Shafaat, H. S.

J. Am. Chem. Soc., 2018, 10.1021/jacs.8b05194


Metal: Ni
Ligand type: Amino acid
Host protein: Rubredoxin (Rd)
Anchoring strategy: Metal substitution
Optimization: Genetic
Reaction: H2 evolution
Max TON: ---
ee: ---
PDB: ---
Notes: TOF = 149 s-1

Nature-Driven Photochemistry for Catalytic Solar Hydrogen Production: A Photosystem I-Transition Metal Catalyst Hybrid

Tiede, D. M.; Utschig, L. M.

J. Am. Chem. Soc., 2011, 10.1021/ja206012r


Metal: Co
Ligand type: Oxime; Pyridine
Host protein: Photosystem I (PSI)
Anchoring strategy: Undefined
Optimization: ---
Reaction: H2 evolution
Max TON: 2080
ee: ---
PDB: ---
Notes: Recalculated TON

Nickel-Substituted Rubredoxin as a Minimal Enzyme Model for Hydrogenase

Shafaat, H. S.

J. Phys. Chem. Lett., 2015, 10.1021/acs.jpclett.5b01750


Metal: Ni
Ligand type: Tetrathiolate
Host protein: Rubredoxin (Rd)
Anchoring strategy: Metal substitution
Optimization: ---
Reaction: H2 evolution
Max TON: 300
ee: ---
PDB: ---
Notes: ---

Photo-Driven Hydrogen Evolution by an Artificial Hydrogenase Utilizing the Biotin-Streptavidin Technology

Alberto, R.; Ward, T. R.

Helv. Chim. Acta, 2018, 10.1002/hlca.201800036


Metal: Co
Ligand type: Bipyridine; Pyridine
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: H2 evolution
Max TON: >1800
ee: ---
PDB: 6FRY
Notes: ---

Photoinduced Hydrogen Evolution Catalyzed by a Synthetic Diiron Dithiolate Complex Embedded within a Protein Matrix

Onoda, A.

ACS Catal., 2014, 10.1021/cs500392e


Metal: Fe
Ligand type: Carbonyl; Dithiolate
Host protein: Nitrobindin (Nb)
Anchoring strategy: Covalent
Optimization: ---
Reaction: H2 evolution
Max TON: 130
ee: ---
PDB: ---
Notes: ---

Protein Delivery of a Ni Catalyst to Photosystem I for Light-Driven Hydrogen Production

Tiede, D. M.; Utschig, L. M.

J. Am. Chem. Soc., 2013, 10.1021/ja405277g


Metal: Ni
Ligand type: Phosphine
Host protein: Flavodoxin (Fld)
Anchoring strategy: Supramolecular
Optimization: ---
Reaction: H2 evolution
Max TON: 94
ee: ---
PDB: ---
Notes: Recalculated TON

Metal: Ni
Ligand type: Phosphine
Host protein: Photosystem I (PSI)
Anchoring strategy: Undefined
Optimization: ---
Reaction: H2 evolution
Max TON: 1870
ee: ---
PDB: ---
Notes: Recalculated TON

Protein Secondary-Shell Interactions Enhance the Photoinduced Hydrogen Production of Cobalt Protoporphyrin IX

Ghirlanda, G.

Chem. Commun., 2014, 10.1039/c4cc06700b


Metal: Co
Ligand type: Porphyrin
Host protein: Myoglobin (Mb)
Anchoring strategy: Metal substitution
Optimization: Genetic
Reaction: H2 evolution
Max TON: 518
ee: ---
PDB: ---
Notes: ---

Reengineering Cyt b562 for Hydrogen Production: A Facile Route to Artificial Hydrogenases

Ghirlanda, G.

Biochim. Biophys. Acta, Bioenerg., 2016, 10.1016/j.bbabio.2015.09.001


Metal: Co
Ligand type: Porphyrin
Host protein: Cytochrome b562
Anchoring strategy: Metal substitution
Optimization: Genetic
Reaction: H2 evolution
Max TON: 1450
ee: ---
PDB: ---
Notes: ---

Ru–protein–Co Biohybrids Designed for Solar Hydrogen Production: Understanding Electron Transfer Pathways Related to Photocatalytic Function

Utschig, L. M.

Chem. Sci., 2016, 10.1039/c6sc03121h


Metal: Co
Ligand type: Oxime
Host protein: Ferredoxin (Fd)
Anchoring strategy: Dative
Optimization: Chemical
Reaction: H2 evolution
Max TON: 650
ee: ---
PDB: ---
Notes: Recalculated TON

Semisynthetic and Biomolecular Hydrogen Evolution Catalysts

Bren, K. L.

Inorg. Chem., 2016, 10.1021/acs.inorgchem.5b02054


Metal: Co
Ligand type: Porphyrin
Host protein: Cytochrome c552
Anchoring strategy: Metal substitution
Optimization: Genetic
Reaction: H2 evolution
Max TON: 27000
ee: ---
PDB: ---
Notes: Electrocatalysis

Spontaneous Activation of [FeFe]-Hydrogenases by an Inorganic [2Fe] Active Site Mimic

Happe, T.

Nat. Chem. Biol., 2013, 10.1038/Nchembio.1311


Metal: Fe
Ligand type: CN; CO; Dithiolate
Anchoring strategy: Dative
Optimization: Chemical
Reaction: H2 evolution
Max TON: ---
ee: ---
PDB: ---
Notes: ---