Control of the Coordination Structure of Organometallic Palladium Complexes in an Apo-Ferritin Cage
J. Am. Chem. Soc. 2008, 130, 10512-10514, 10.1021/ja802463a
We report the preparation of organometallic Pd(allyl) dinuclear complexes in protein cages of apo-Fr by reactions with [Pd(allyl)Cl]2 (allyl = η3-C3H5). One of the dinuclear complexes is converted to a trinuclear complex by replacing a Pd-coordinated His residue to an Ala residue. These results suggest that multinuclear metal complexes with various coordination structures could be prepared by the deletion or introduction of His, Cys, and Glu at appropriate positions on protein surface.
Definite Coordination Arrangement of Organometallic Palladium Complexes Accumulated on the Designed Interior Surface of Apo-Ferritin
Chem. Commun. 2011, 47, 170-172, 10.1039/C0CC02221G
Apo-ferritin (apo-Fr) mutants are used as scaffolds to accommodate palladium (allyl) complexes. Various coordination arrangements of the Pd complexes are achieved by adjusting the positions of cysteine and histidine residues on the interior surface of the apo-Fr cage.
Polymerization of Phenylacetylene by Rhodium Complexes within a Discrete Space of apo-Ferritin
J. Am. Chem. Soc. 2009, 131, 6958-6960, 10.1021/ja901234j
Polymerization reactions of phenylacetylene derivatives are promoted by rhodium complexes within the discrete space of apo-ferritin in aqueous media. The catalytic reaction provides polymers with restricted molecular weight and a narrow molecular weight distribution. These results suggest that protein nanocages have potential for use as various reaction spaces through immobilization of metal catalysts on the interior surfaces of the protein cages.
Metal: RhLigand type: NorbornadieneOptimization: ---Reaction: Phenylacetylene polymerizationMax TON: ---ee: ---PDB: 2ZURNotes: ---