4 publications

4 publications

Artificial Metalloenzymes for Hydrogenation and Transfer Hydrogenation Reactions

Review

Klein Gebbink, R.J.M.

Artificial Metalloenzymes and MetalloDNAzymes in Catalysis: From Design to Applications, 2018, 10.1002/9783527804085.ch6


Notes: Book chapter

Covalent Anchoring of a Racemization Catalyst to CALB-Beads: Towards Dual Immobilization of DKR Catalysts

Klein Gebbink, R.J.M.; van Koten, G.

Tetrahedron Lett., 2011, 10.1016/j.tetlet.2011.01.106


Metal: Ru
Anchoring strategy: Covalent
Optimization: Chemical
Reaction: Acylation
Max TON: ---
ee: >99%
PDB: ---
Notes: Lipase CALB is immobilized on a solid support (Novozym®435). Dynamic kinetic resolution (DKR) of 1-phenylethanol to the acylated product.

Lipase Active Site Covalent Anchoring of Rh(NHC) Catalysts: Towards Chemoselective Artificial Metalloenzymes

Klein Gebbink, R.J.M.

Chem. Commun., 2015, 10.1039/c4cc09700a


Metal: Rh
Ligand type: Carbene
Host protein: Cutinase
Anchoring strategy: Covalent
Optimization: ---
Reaction: Hydrogenation
Max TON: 20
ee: rac.
PDB: 1CEX
Notes: ---

Metal: Rh
Ligand type: Carbene
Anchoring strategy: Covalent
Optimization: ---
Reaction: Hydrogenation
Max TON: 20
ee: rac.
PDB: 4K6G
Notes: ---

Ring-Closing and Cross-Metathesis with Artificial Metalloenzymes Created by Covalent Active Site- Directed Hybridization of a Lipase

Klein Gebbink, R.J.M.

Chem. - Eur. J., 2015, 10.1002/chem.201502381


Metal: Ru
Ligand type: Carbene
Host protein: Cutinase
Anchoring strategy: Covalent
Optimization: Chemical
Reaction: Olefin metathesis
Max TON: 17
ee: ---
PDB: ---
Notes: RCM

Metal: Ru
Ligand type: Carbene
Host protein: Cutinase
Anchoring strategy: Covalent
Optimization: Chemical
Reaction: Olefin metathesis
Max TON: 20
ee: ---
PDB: ---
Notes: Cross metathesis