4 publications

4 publications

Artificial Metalloproteins Containing Co4O4 Cubane Active Sites

Borovik, A. S.; Don Tilley, T.

J. Am. Chem. Soc., 2018, 10.1021/jacs.7b13052


Metal: Co
Ligand type: OAc; Pyridine
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: ---
ee: ---
PDB: 6AUC
Notes: Co-complex in Sav WT

Metal: Co
Ligand type: OAc; Pyridine
Host protein: Streptavidin (Sav)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Max TON: ---
ee: ---
PDB: 6AUE
Notes: Co-complex in Sav S112Y

Asymmetric δ-Lactam Synthesis with a Monomeric Streptavidin Artificial Metalloenzyme

McNaughton, B. R.; Rovis, T.

J. Am. Chem. Soc., 2019, 10.1021/jacs.9b01596


Metal: Rh
Ligand type: Cp*; OAc
Host protein: Streptavidin (monmeric)
Anchoring strategy: Supramolecular
Optimization: Chemical & genetic
Reaction: Lactam synthesis
Max TON: 33
ee: 97
PDB: ---
Notes: ---

Diruthenium Diacetate-Catalyzed Aerobic Oxidation of Hydroxylamines and Improved Chemoselectivity by Immobilization to Lysozyme

Cardona, F.; Goti, A.; Messori, L.

ChemCatChem, 2017, 10.1002/cctc.201701083


Metal: Ru
Ligand type: Amino acid; OAc
Host protein: Lysozyme
Anchoring strategy: Dative
Optimization: Chemical
Max TON: 1000
ee: ---
PDB: ---
Notes: ---

Evolving Artificial Metalloenzymes via Random Mutagenesis

Lewis, J. C.

Nat. Chem., 2018, 10.1038/nchem.2927


Metal: Rh
Ligand type: OAc
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Reaction: Cyclopropanation
Max TON: 66
ee: 94
PDB: 5T88
Notes: Mutagenesis of the ArM by error-prone PCR

Metal: Rh
Ligand type: OAc
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Reaction: N-H Insertion
Max TON: 73
ee: 40
PDB: 5T88
Notes: Mutagenesis of the ArM by error-prone PCR

Metal: Rh
Ligand type: OAc
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Reaction: S-H Insertion
Max TON: 64
ee: 32
PDB: 5T88
Notes: Mutagenesis of the ArM by error-prone PCR

Metal: Rh
Ligand type: OAc
Anchoring strategy: Covalent
Optimization: Chemical & genetic
Reaction: Si-H Insertion
Max TON: 35
ee: 64
PDB: 5T88
Notes: Mutagenesis of the ArM by error-prone PCR