1 publication
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Peroxidase Activity of an Antibody-Heme Complex
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J. Am. Chem. Soc. 1990, 112, 9414-9415, 10.1021/ja00181a065
The specificity and diversity of the immune system have recently been exploited in the generation of antibodies that catalyze a wide variety of chemical reactions.1·2 Several general strategies for the design of catalytic antibodies have emerged, including the use of antibody binding energy to enhance the chemical reactivity of a cofactor or to position a cofactor and a substrate in close proximity.3,4 An intriguing target for antibody-cofactor catalysis is the oxidative reactions characteristic of heme proteins. Here we report that antibodies specific for A-methylmesoporphyrin IX bind iron(III) mesoporphyrin IX and that the resulting complex catalyzes the oxidation of several substrates. These studies are a first step toward the development of selective antibody-heme monooxygenase catalysts.
Metal: FeLigand type: PorphyrinHost protein: Antibody7G12-A10-G1-A12Anchoring strategy: SupramolecularOptimization: ---Notes: ---